{"id":3715,"date":"2022-09-01T00:24:10","date_gmt":"2022-09-01T00:24:10","guid":{"rendered":"https:\/\/inbre.hpcf.upr.edu\/?page_id=3715"},"modified":"2022-09-01T00:32:10","modified_gmt":"2022-09-01T00:32:10","slug":"dr-marcos-lopez","status":"publish","type":"page","link":"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-marcos-lopez\/","title":{"rendered":"Dr. Marcos Lopez"},"content":{"rendered":"<p><section data-kc-fullwidth=\"row\" class=\"kc-elm kc-css-582809 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-878297 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-820623\" style=\"height: 200px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-152320 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-939037 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-801631 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2022\/08\/DrMarcosLopez.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-765474 kc-title-wrap \">\n\n\t<h2 class=\"kc_title\">Dr. Marcos Lopez<\/h2>\n<\/div>\n<div class=\"kc-elm kc-css-149350 kc_text_block\"><\/p>\n<p><strong>Institution:<\/strong> UPR &#8211; Humacao Campus<\/p>\n<p><strong>Email:<\/strong> marcos.lopez11@upr.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-842405 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-677817 kc-title-wrap \">\n\n\t<h3 class=\"kc_title\">Targeting triple-negative breast cancer mitochondrial metabolism and bioenergetics<\/h3>\n<\/div>\n<div class=\"kc-elm kc-css-342610 kc_text_block\"><\/p>\n<p>Triple-negative breast cancer (TNBC) is one of the most aggressive forms of breast cancer. TNBC tumors are not responsive to standard endocrine therapies and often exhibit resistance. For patients with metastatic disease, the median overall survival is estimated to be less than 18 months. Thus, there is a critical unmet need for new therapies to treat patients with TNBC. Advancing research in cancer therapy is focused on exploiting the biochemical differences between cancer and normal cell metabolism. Emerging evidence has shown that distinct tumor-specific metabolic changes, including reliance on aerobic glycolysis and changes in mitochondrial bioenergetics, are critical drivers of malignancy in TNBC. Previously, we<br \/>demonstrated that mitochondrial metabolism and reactive oxygen species (ROS) are essential for tumorigenicity. In addition, it has been reported that TNBC cells exhibit elevated glycolysis and increased generation of ROS compared to non-TNBC cells. The main goal of this project is to develop new therapeutic approaches to inhibit TNBC by targeting mitochondrial metabolism and bioenergetics. The significance of the proposed work lies in the use of relatively non-toxic mitochondria-targeted SG-1 nitroxide that disrupts mitochondrial metabolism and bioenergetics to inhibit TNBC cell proliferation and metastasis. First, we will assess the efficacy of Mito-SG1 in TNBC tumor cells. Then, we will use innovative extracellular flux analyses (Seahorse XFe-96) to investigate bioenergetic changes in human TNBC cells. Finally, we will screen the in-vivo efficacy of Mito-SG1 to mitigate TNBC. Successful completion of these aims will increase our understanding of the role of metabolism, mitochondrial bioenergetics, and energysensing in TNBC cancer malignancy.<\/p>\n<p>\n<\/div><\/div><\/div><\/div><\/div><\/section><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"_links":{"self":[{"href":"https:\/\/inbre.hpcf.upr.edu\/index.php\/wp-json\/wp\/v2\/pages\/3715"}],"collection":[{"href":"https:\/\/inbre.hpcf.upr.edu\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/inbre.hpcf.upr.edu\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/inbre.hpcf.upr.edu\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inbre.hpcf.upr.edu\/index.php\/wp-json\/wp\/v2\/comments?post=3715"}],"version-history":[{"count":8,"href":"https:\/\/inbre.hpcf.upr.edu\/index.php\/wp-json\/wp\/v2\/pages\/3715\/revisions"}],"predecessor-version":[{"id":3723,"href":"https:\/\/inbre.hpcf.upr.edu\/index.php\/wp-json\/wp\/v2\/pages\/3715\/revisions\/3723"}],"wp:attachment":[{"href":"https:\/\/inbre.hpcf.upr.edu\/index.php\/wp-json\/wp\/v2\/media?parent=3715"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}