{"id":3097,"date":"2022-08-10T14:59:13","date_gmt":"2022-08-10T14:59:13","guid":{"rendered":"https:\/\/inbre.hpcf.upr.edu\/?page_id=3097"},"modified":"2024-05-29T12:27:33","modified_gmt":"2024-05-29T12:27:33","slug":"drpp-core","status":"publish","type":"page","link":"https:\/\/inbre.hpcf.upr.edu\/index.php\/drpp-core\/","title":{"rendered":"DRPP Core"},"content":{"rendered":"<p><section data-kc-fullwidth=\"row\" class=\"kc-elm kc-css-271525 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-722543 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-958352\" style=\"height: 10px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-891164 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-95189 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-207246\" style=\"height: 61px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-393864 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-594418 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-1768 kc-title-wrap \">\n\n\t<h2 class=\"kc_title stage-title font-md lil-line\">Developmental Research Project Program (DRPP) Core<\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-244268 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-136577 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-914970\" style=\"height: 40px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-84635 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-331760 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-976083 kc_text_block\"><\/p>\n<p class=\"MsoListParagraphCxSpFirst\" style=\"margin-left: 0in; mso-add-space: auto;\"><span style=\"mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;\">The DRPP Core support the career development of promising early-stage investigators at Lead and network institutions. Also, provide research opportunities through professional mentoring and financial support to enhance the research capabilities of network investigators in the four program thematic areas: <b><i>Neuroscience\/Behavior, Molecular Medicine\/Cancer, Drug<span style=\"mso-spacerun: yes;\">\u00a0 <\/span>Discovery\/Development, and Bioinformatics<\/i><\/b><\/span><\/p>\n<p class=\"MsoListParagraphCxSpMiddle\" style=\"margin-left: 0in; mso-add-space: auto;\"><span style=\"mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;\">This program is highly significant for the training and implementation of the PR research enterprise and is expected to impact the unique health problems of the Puerto Rican population. To this end, Dr. Suranganie Dharmawardhane, the DRPP Director and PC, will work with the PI, Dr. Jose R. Rodriguez-Medina to continue to increase and develop the talent pool in PR, and reverse the general decline in federal resources for biomedical research by supporting meritorious research that proposes to use evidence-based findings to improve human health and fill critical gaps in our current knowledge base.<\/span><\/p>\n<p class=\"MsoListParagraphCxSpLast\" style=\"margin-left: 0in; mso-add-space: auto;\"><span style=\"mso-bidi-font-family: Calibri; mso-bidi-theme-font: minor-latin;\">The DRPP identify promising investigators and Postdoctoral fellows in the early stages of their careers, and provide them with not just financial support, but individualized mentoring and a cohesive research infrastructure. The DRPP proposes to encourage interdisciplinary research among the INBRE and COBRE institutions, increase the number of extramural funds awarded to the DRPP investigators, augment the quality of PR-INBRE investigators\u2019 publications, and mentor qualified investigators to obtain independent funding. These strategies are expected to result in a highly trained cadre of underrepresented scientists ultimately contributing to health benefits and increased diversity in the biomedical sciences. <\/span><\/p>\n<h4><strong>Funds Opportunities<\/strong><\/h4>\n<ul>\n<li><strong>Full Projects: <\/strong>Research support will be provided collaborative research projects selected from promising early investigators in the PR-INBRE network PUIs. The initial awards of $100,000\/yr. will be for a period of three years, with the potential for renewal for the next two years, dependent on need and productivity. Click <a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/grant-application-and-instructions\/\">here<\/a> to view\/download FOA, grant applications and instructions.<\/li>\n<li><strong>Pilot Projects:<\/strong> Research support will provide seed funds for collaborative pilot projects from postdoctoral researchers and faculty from network and Outreach Institutions. The awards will be $50,000\/yr. for two years, and one year in the 5th year of funding. A new initiative is the support of early investigators at the lead institutions, via the Administrative Core as start-up or bridge funds using the same solicitation and competitive review mechanisms for the partner institutions. Click <a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/grant-application-and-instructions\/\">here<\/a> to view\/download FOA, grant applications and instructions.<\/li>\n<li><strong>Instrumentation Grants:<\/strong> These grants will be awarded to faculty at PUIs, dependent on their collaborative research needs. This mechanism is not intended to duplicate the existing research infrastructure of the core facilities of the lead institutions but complement their research capabilities by funding the needs for small instrumentation in the laboratories and\/or core facilities of the PUIs.<\/li>\n<li><strong>Feasability Grants:<\/strong> Small grants will be awarded to faculty for INBRE core facility use. These grants will be based on the collaborative needs of one or more investigators in participating institutions and will fulfill specific use of the INBRE core facilities to gather \u201comics\u201d type data necessary to complete a specified research project, resubmit a manuscript or grant application as per reviewer critiques, or to gather preliminary data for grant applications.<\/li>\n<\/ul>\n<p>\n<\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-586269 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-865233 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-84223 kc-title-wrap \">\n\n\t<h3 class=\"kc_title stage-title font-md lil-line\">DRPP Investigators<\/h3>\n<\/div>\n<\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-678839 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-983333 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-60239\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-68937 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-69360 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-79340 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2022\/08\/DrNawal-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-490170 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Boukli, Nawal, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-853277 kc_text_block\"><\/p>\n<p>\nUniversidad Central del Caribe<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-930990 kc_text_block\"><\/p>\n<p>\nnbouli@uccaribe.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-219199 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-19226 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Gp12O Promotes ER Stress Response and Chemotherapy Resistance<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-230683 kc_text_block\"><\/p>\n<p>\nThis project is designed to reduce cancer disparities of GBM (the most deadly primary brain tumor) among HIV-infected population. The identified mechanisms of HIV-driven glioma growth and treatment resistance will serve as a basis for the development of novel therapeutic targets. The outcome from this study will outline the avenue for the development of new and effective treatment methods for HIV glioma patients.<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-nawal-boukli\/\" title=\"Dr. Nawal Boukli\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-381379\">View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-985615 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-782793 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-373590\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-39807 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-768967 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-271129 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2023\/04\/Dr-Antonio-Colom-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-283331 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Colom, Antonio, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-394216 kc_text_block\"><\/p>\n<p>\nInteramerican University Metropolitan Campus<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-907558 kc_text_block\"><\/p>\n<p>\nacolom@intermetro.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-415311 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-352091 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Investigating potential biding sites of 2-HDA in Fabl from S. Aureus by Computational Methods<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-256832 kc_text_block\"><\/p>\n<p>\nMethicillin resistant S.aureus is a pathogen that causes a diverse array of infections and new antibiotics are urgently needed. This project will identify the biding mode of an antibacterial fatty acid, 2-HDA, to the aureus reductase Fabl, providing and insight of the inhibitory mechanism of this molecule.<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-antonio-colom\/\" title=\"Dr. Antonio Colom\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-770407\">View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-128785 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-142069 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-810888\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-963004 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-489648 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-733395 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2023\/04\/Dr-Emmanuel-Cruz-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-301874 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Cruz, Emmanuel, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-797408 kc_text_block\"><\/p>\n<p>\nPontifical Catholic University of P.R.<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-725202 kc_text_block\"><\/p>\n<p>\nemmanuel_cruz@pucpr.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-826965 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-915125 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">The Metabolomic Profile of the Angelman Syndrome Brain<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-952632 kc_text_block\"><\/p>\n<p>\nThere is no current specific treatment for Angelman Syndrome and the brain metabolome of this disease is completely unknown. We will use OMICs to identify changes in specific metabolic pathways in the brain of AS mice compared to control conditions. These studies may identify novel metabolic pathways that can be targeted as possible treatments for this disease.<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-emmanuel-ortiz\/\" title=\"Dr. Emmanuel Ortiz\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-237050\">View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-354434 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-977253 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-39979\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-787272 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-966715 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-598832 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2022\/08\/DrLisandroCunci-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-527386 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Cunci, Lisandro, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-669897 kc_text_block\"><\/p>\n<p>\nAna G. M\u00e9ndez Gurabo Campus<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-729544 kc_text_block\"><\/p>\n<p>\ncuncil1@uagm.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-147143 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-299369 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Multielectrode spatial mapping of neurotransmitters and neuropeptides in acute brain slices<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-674768 kc_text_block\"><\/p>\n<p>\nNeuropeptide Y (NPY) is a highly potent anxiolytic known to be released in the hippocampus affecting many behaviors related to stress disorders such as Post-Traumatic Stress Disorder (PTSD) and there is currently no analytical technique or equipment that is able to measure neuropeptides, neurotransmitters and extracellular potentials in the brain with sub-second temporal resolution. In this proposal, a modular hardware and software required for this system will be developed for fast electrochemical techniques as well as continuous electrochemical impedance measurements that will be validated using rats brain slices. In this way, we will be able to provide an enhanced view of the chemical environment to filter the signal caused by different neurotransmitters and neuropeptides.<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-lisandro-cunci\/\" title=\"Dr. Lisandro Cunci\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-600235\">View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-95441 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-991422 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-404934\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-86381 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-754905 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-829553 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2022\/08\/DrNatashaDeLeon-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-562850 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">De Le\u00f3n, Natasha, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-773910 kc_text_block\"><\/p>\n<p>\nInteramerican University Metropolitan Campus<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-425717 kc_text_block\"><\/p>\n<p>\nndeleon@intermetro.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-206735 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-440975 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Effects of exercise on fear- and cocaine-induced changes in the nucleus accumbens<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-312540 kc_text_block\"><\/p>\n<p>\nThe proposed research is relevant to public health because substance abuse disorder has a high rate of comorbidity with anxiety disorders. Aerobic exercise is a promising, non-pharmacological therapy that can be incorporated into treatment for the comorbidity of PTSD and cocaine addiction. The overall goal of the proposed study is to identify the mechanism by which aerobic exercise reduces cocaine-seeking behavior in animal models of addiction and PTSD.<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-natasha-de-leon\/\" title=\"Dr. Natasha de Leon\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-240559\">View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-307779 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-874690 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-354539\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-434416 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-654020 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-515312 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2023\/03\/DrCarlosDiaz-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-943594 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">D\u00edaz, Carlos, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-612002 kc_text_block\"><\/p>\n<p>\nPonce Medical School Foundation Inc<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-940048 kc_text_block\"><\/p>\n<p>\ncjdiaz@psm.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-490630 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-30415 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Immunometabolomic profiling of prostate cancer in Puerto Rican men<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-177409 kc_text_block\"><\/p>\n<p>\nThe Hispanic\/Latino (H\/L) population is projected to comprise over 30% of the U.S. population in the next 30 years and Puerto Ricans suffer the highest rates of prostate cancer incidence and mortality among H\/L groups. The biological contributors to this disparity are currently unknown, and their elucidation has a strong potential to inform clinical risk stratification. The purpose of this study is to identify biomarkers relevant to the Puerto Rican population to enhance the identification of aggressive prostate cancer with the goal of eliminating prostate cancer disparities in Puerto Rican men.<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-carlos-diaz\/\" title=\"Dr. Carlos Diaz\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-838660\">View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-659289 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-889079 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-523777\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-184206 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-123222 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-406369 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2022\/08\/DraYancyFerrer-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-794081 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Ferrer, Yancy, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-60851 kc_text_block\"><\/p>\n<p>\nUniversidad Central del Caribe<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-287870 kc_text_block\"><\/p>\n<p>\nyancy.ferrer@uccaribe<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-434671 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-853356 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Effects of phytonutrients in resistance and metastasis in lug carcinoma<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-559718 kc_text_block\"><\/p>\n<p>\nThe long-term outcome that makes this proposal relevant is the development of plant-based nanosuspensions which have enhanced gastrointestinal absorption, increasing the activity of the anticancer phytochemicals. These NS can be combined with current chemotherapy to treat the deadliest and most common lung cancer, NSCLC. The phyto-NS therapy will be an accessible adjuvant treatment that could be critical in countries where modern drugs or health facilities are not abundant. Approaches testing different phyto-NS will lead to more personalized, targeted cancer treatments.<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-yancy-ferrer\/\" title=\"Dr. Yancy Ferrer\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-619852\">View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-49582 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-777179 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-24083\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-133974 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-952587 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-506279 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2022\/08\/DrYalizLoperana-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-629908 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Loperana, Yaliz, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-422726 kc_text_block\"><\/p>\n<p>\nPontifical Catholic University of P.R.<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-982863 kc_text_block\"><\/p>\n<p>\nyaliz_loperena@pucpr.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-841268 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-738729 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Crosstalk between C. neformans\/gattii and macrophages in the development of titan cells<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-887691 kc_text_block\"><\/p>\n<p>\nThe aims for the project are: 1. Determine the differences of the capsule pathogenesis between C. neoformans and C. gattii. This data will be the basis for the development of new treatment strategies against the yeast complex. 2. Established which of the secreated productos of the macrophages is triggering the development of titan cells, which will help us to understand the regulation of the capsule. 3. Define the effect of C. neoformans\/gattii in the inhibition of phagocytosis by inducing polarization of macrophages<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-yaliz-loperana\/\" title=\"Dr. Yaliz Loperana\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-80933\"> View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-380550 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-159124 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-680159\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-340848 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-223327 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-74041 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2022\/08\/DrMarcosLopez-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-73303 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">L\u00f3pez, Marcos, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-17190 kc_text_block\"><\/p>\n<p>\nUPR Humacao Campus<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-795269 kc_text_block\"><\/p>\n<p>\nmarcos.lopez11@upr.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-870212 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-435000 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Targeting triple-negative breast cancer mitochondrial metabolism and bioenergetics<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-564670 kc_text_block\"><\/p>\n<p>\nMore than 280,000 women in the United States will be newly diagnosed with breast cancer in 2021. Unfortunately, there is a lack of drugs to treat patients with TNBC. The strategy of the proposed studies is to inhibit bioenergetic metabolism with relatively non-toxic mitochondria-targeted Mito-SG1 to inhibit TNBC cell proliferation and metastasis and improve the health of patients with TNBC.<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-marcos-lopez\/\" title=\"Dr. Marcos Lopez\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-480276\">View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-595661 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-322811 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-587995\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-866081 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-981404 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-605624 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2022\/08\/DrAntonioMartins-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-433232 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Martins, Antonio, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-903213 kc_text_block\"><\/p>\n<p>\nUPR &#8211; Medical Science Campus<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-922840 kc_text_block\"><\/p>\n<p>\nantonio.martins@upr.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-32695 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-320486 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Identification of the molecular mechanisms of the blood-brain barrier disruption by the NG291 peptide<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-145602 kc_text_block\"><\/p>\n<p>\nThe selectivity of blood-brain barrier transport is so robust that it prevents the uptake of pharmaceuticals, creating one of the biggest challenges in treating the central nervous system. We will use a stable peptide to transiently open the blood-brain barrier to increase the permeation of drugs that regularly do not cross the blood-brain barrier.<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-antonio-martins\/\" title=\"Dr. Antonio Martins\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-689555\">View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-113758 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-38868 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-152323\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-707774 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-735 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-109202 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2023\/03\/DraPatricia-Ortiz-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-100042 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Ortiz, Patricia, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-532056 kc_text_block\"><\/p>\n<p>\nUniversity of Puerto Rico Mayag\u00fcez Campus<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-537425 kc_text_block\"><\/p>\n<p>patricia.ortiz3@upr.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-900163 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-890132 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Unraveling modulators of polymicrobial interactions in human disease<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-210742 kc_text_block\"><\/p>\n<p>\nHuman pathogens thrive through association with multiple cell types and their interaction with the extracellular matrix (ECM), are often structured as biofilms. Functional metagenomics provides a combinatorial, culture-independent, inexpensive platform to uncover polymicrobial interactions in the context of human disease, allowing diverse strategies to recreate testing substrates such as the ECM. This project involves the screening and characterization of metagenomic libraries expressed in model bacteria, to dissect modulators of the human fungal pathogen Candida albicans biofilms in the presence of ECM components.<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-patricia-ortiz\/\" title=\"Dr. Patricia Ortiz\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-692672\">View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-720444 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-901862 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-681739\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-193844 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-327760 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-741224 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2023\/04\/Dra-Claudia-Ospina-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-457304 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Ospina, Claudia, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-910085 kc_text_block\"><\/p>\n<p>\nInteramerican University Bayam\u00f3n Campus<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-175753 kc_text_block\"><\/p>\n<p>\ncospina@bayamon.inter.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-23607 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-869572 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Anticancer Potential and Nanocarrier Design of Quassinoids of Simaarouba<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-832187 kc_text_block\"><\/p>\n<p>\nMore than 1.9 million new cases of cancer are expected to be diagnosed and 608,570 Americans will die from this disease in 2021. Our project aims to discover new anticancer agents and to the development of novel and safe natural products formulations to treat a disease that causes high mortality worldwide.<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-claudia-ospina\/\" title=\"Dr. Claudia Ospina\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-129784\">View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-29655 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-209219 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-814813\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-476878 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-636004 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-989521 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2022\/08\/Dra-Elsie-Pares-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-202236 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Pares, Elsie, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-52070 kc_text_block\"><\/p>\n<p>\nUniversity of Puerto Rico Mayag\u00fcez Campus<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-593899 kc_text_block\"><\/p>\n<p>\nelsie.pares@upr.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-954203 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-509788 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Understanding the molecular action of potential target drugs against Ras2p during cell wall integrity signaling pathways in yeast.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-405733 kc_text_block\"><\/p>\n<p>\nA better understanding of the cell wall integrity pathway can help us to find and develop new drugs that could inhibit cell wall remodeling under cell wall stress. These cytoplasmic tails are promising targets for the development of antifungal drugs against pathogenic fungi such as Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus.<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-elsie-pares\/\" title=\"Dr. Elsie Par\u00e9s\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-526653\">View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-891387 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-16956 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-748580\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-170724 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-477823 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-669444 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2023\/03\/Dr.DavidRivera-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-351345 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Rivera, David, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-227969 kc_text_block\"><\/p>\n<p>\nUniversidad Central del Caribe<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-891916 kc_text_block\"><\/p>\n<p>\ndavid.rivera@uccaribe.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-592877 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-68209 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Diabetes and Astrocytes: impact on normal astrocyte function and its consequences<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-71065 kc_text_block\"><\/p>\n<p>\nDiabetic patients have a higher risk of suffering from a stroke when compared to non-diabetics and the brain damage that occurs may be more severe or extensive if blood glucose levels are high when a stroke happens. The proposed studies will examine AMPK regulatory function on the expression of Kir4.1 as a possible molecular mechanism by which hyperglycemia affects astrocytic functions. Our findings will improve current knowledge and help develop novel therapeutic agents for this disease.<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-david-rivera\/\" title=\"Dr. David Rivera\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-931418\">View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-940885 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-651141 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-228123\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-646436 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-906709 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-313319 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2023\/04\/Dra-Abigail-Ruiz-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-248723 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Ruiz, Abigail, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-370077 kc_text_block\"><\/p>\n<p>\nUPR Ponce Campus<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-347161 kc_text_block\"><\/p>\n<p>\nabigail.ruiz@upr.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-660396 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-184529 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">In vivo efficacy of the CXCR4 inhibitor AMD3100 in the rat model of endometriosis<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-998600 kc_text_block\"><\/p>\n<p>\nEndometriosis affects millions of women around the world impacting their daily lives. Current research has also demonstrated an increase in other chronic diseases in endometriosis patients. Using an in vivo model this project will contribute towards the identification of additional treatments targeting novel molecular mechanisms.<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-abigail-rivera\/\" title=\"Dr. Abigail Rivera\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-560476\">View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-795464 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-923361 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-937039\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-479577 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-154015 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-577507 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2022\/08\/DrIrisSalgado-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-658974 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Salgado, Iris, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-632971 kc_text_block\"><\/p>\n<p>\nUniversidad Central del Caribe<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-404762 kc_text_block\"><\/p>\n<p>\niris.salgado@uccaribe.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-347097 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-707246 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Potential mechanism of action of selected lead compounds with influenza antiviral activity<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-659598 kc_text_block\"><\/p>\n<p>\nInfluenza is a highly infectious and potentially deadly acute respiratory disease of widespread global epidemic and pandemic proportions. It is caused by the infection of the influenza-A (INF-A) virus and B virus in humans. Limited pharmacotherapy and the emergence of resistant strains underscore the need for effective treatments with limited resistance development. Describing the mechanism of our lead compounds will guide this project to its development until the translational stage. Now, more than ever, we need to be prepared before the occurrence of a new influenza virus strain that could emerge in a new pandemic event.<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-iris-salgado\/\" title=\"\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-160877\">View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-715032 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-265809 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-162226\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-830743 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-470242 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-83362 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2023\/04\/Dr-David-Sanabria-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-524619 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Sanabria, David, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-635134 kc_text_block\"><\/p>\n<p>\nInteramerican University Bayam\u00f3n Campus<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-703812 kc_text_block\"><\/p>\n<p>\ndsanabria@intermetro.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-102566 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-557179 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Investigating the effect of unsaturated fatty acids on the integrity of Staphylococcus aureus<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-976765 kc_text_block\"><\/p>\n<p>\nMethicillin-resistant S. aureus (MRSA) is a serious concern since this pathogen continues gaining resistance to current antibiotics. This proposal combines molecular, spectroscopic, and chemical approaches for a comprehensive understanding of how synthetic unsaturated fatty acids (uFA) interact with S. aureus cell membrane. These studies may lead to the development of nextgeneration of uFA with even greater efficacy as antibacterial agents.<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-david-sanabria\/\" title=\"Dr. David Sanabria\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-642771\">View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-16406 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-285480 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-271579\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-310497 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-365032 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-610123 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2022\/08\/DraMarianSepulveda-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-781543 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Sep\u00falveda, Marian, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-222642 kc_text_block\"><\/p>\n<p>\nPonce Medical School Foundation Inc<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-523842 kc_text_block\"><\/p>\n<p>\nmsepulveda@psm.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-743173 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-295720 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Effects of exercise on fear- and cocaine-induced changes in the nucleus accumbens<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-567367 kc_text_block\"><\/p>\n<p>\nThe proposed research is relevant to public health because substance abuse disorder has a high rate of comorbidity with anxiety disorders. Aerobic exercise is a promising, non-pharmacological therapy that can be incorporated into treatment for the comorbidity of PTSD and cocaine addiction. The overall goal of the proposed study is to identify the mechanism by which aerobic exercise reduces cocaine-seeking behavior in animal models of addiction and PTSD.<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-marian-sepulveda\/\" title=\"Dr. Marian Sep\u00falveda\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-73828\">View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-334985 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-258932 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-622364\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-709792 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-183203 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-114937 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2022\/08\/DrEduSuarez-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-859624 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Suarez, Edu, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-483611 kc_text_block\"><\/p>\n<p>\nUPR Ponce Campus<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-887719 kc_text_block\"><\/p>\n<p>\nedu.suarez@upr.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-628731 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-706723 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Asthma & Persistent Allergic Rhinitis: Cytokine - Specific Profile and Expression of Pro-Inflammatory Molecules in the Puerto Rican Population<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-566385 kc_text_block\"><\/p>\n<p>\nAsthma and persistent allergic rhinitis (PAR) are two complex, chronic, heterogeneous disorders, with including inflammation of the airways and showing high prevalence in Puerto Rico. For is difficult and require specialized physicians and tests not always accessible to some populations. Our contribution previously identified human proinflammatory differentially expressed between asthmatics, allergic asthmatics, persistent allergic, and controls to obtain the biological data required to create a population-based specific medical device as effective and accessible tool for phenotypes. similar symptomatology including inflammation of the airways and both show a high prevalence in Puerto Rico. For instance, a differential diagnosis is difficult and require specialized physicians and tests not always accessible to some sub- populations. Our contribution with this study, will be to validate our previously identified human proinflammatory molecules panel differentially expressed between asthmatics, allergic asthmatics, persistent\u00a0 allergic, and controls to obtain the biological data required to create a population-based specific effective medical device with accessibility for diagnosis of asthma and PAR phenotypes and as a consequence the specified pharmacological treatment.<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-edu-suarez\/\" title=\"\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-299616\">View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-81251 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-780099 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-231533\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-669229 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-85711 kc_col-sm-4 kc_column kc_col-sm-4\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-411595 kc_shortcode kc_single_image\">\n\n        <img src=\"https:\/\/inbre.hpcf.upr.edu\/wp-content\/uploads\/2022\/08\/DrCeidyTorres-260x270xc.jpg\" class=\"\" alt=\"\" \/>    <\/div>\n\n<div class=\"kc-elm kc-css-929878 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Torres, Ceidy, PhD.<\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-119673 kc_text_block\"><\/p>\n<p>\nPontifical Catholic University of P.R.<\/p>\n<p>\n<\/div><div class=\"kc-elm kc-css-497060 kc_text_block\"><\/p>\n<p>\nceidy_torres@pucpr.edu<\/p>\n<p>\n<\/div><\/div><\/div><div class=\"kc-elm kc-css-913052 kc_col-sm-8 kc_column kc_col-sm-8\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-975537 kc-title-wrap \">\n\n\t<h4 class=\"kc_title\">Mithopagy and SOD1G93A Mutation Associated to Amyotrophic Lateral Sclerosis  using Yeast Model <\/h4>\n<\/div>\n<div class=\"kc-elm kc-css-144969 kc_text_block\"><\/p>\n<p>\nMitophagy mechanism shares common features between yeast and mammals. Understanding the physiological role of mitophagy, it can be a possible target mechanism for treatments to deal with neurodegenerative diseases, cancer and aging characterized by mitochondrial dysfunction and high levels of reactive oxygen species production.<\/p>\n<p>\n<\/div><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/dr-ceidy-torres\/\" title=\"Dr. Ceidy Torres\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-635585\">View Abstract<\/a><\/div><\/div><\/div><\/div><\/section><section class=\"kc-elm kc-css-816754 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-206710 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-761047\" style=\"height: 20px; clear: both; width:100%;\"><\/div><\/div><\/div><\/div><\/div><\/section><section data-kc-fullwidth=\"row\" class=\"kc-elm kc-css-980493 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-160500 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\">\n<div class=\"kc-elm kc-css-174551 kc-title-wrap \">\n\n\t<h1 class=\"kc_title\">Our Staff<\/h1>\n<\/div>\n<\/div><\/div><\/div><\/div><\/section><section data-kc-fullwidth=\"row\" class=\"kc-elm kc-css-580104 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-137917 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><div class=\"kc-elm kc-css-293999 kc_text_block\"><\/p>\n<p>\nMeet PRINBRE Cores Directors and Staff Members<\/p>\n<p>\n<\/div><\/div><\/div><\/div><\/div><\/section><section data-kc-fullwidth=\"row\" class=\"kc-elm kc-css-839655 kc_row\"><div class=\"kc-row-container  kc-container\"><div class=\"kc-wrap-columns\"><div class=\"kc-elm kc-css-873102 kc_col-sm-12 kc_column kc_col-sm-12\"><div class=\"kc-col-container\"><a href=\"https:\/\/inbre.hpcf.upr.edu\/index.php\/contact-us\/\" title=\"Contact Us\" target=\"_self\" class=\"btn btn-action btn-gules kc-elm kc-css-134618\">CONTACT PAGE<\/a><\/div><\/div><\/div><\/div><\/section><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":5203,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0},"_links":{"self":[{"href":"https:\/\/inbre.hpcf.upr.edu\/index.php\/wp-json\/wp\/v2\/pages\/3097"}],"collection":[{"href":"https:\/\/inbre.hpcf.upr.edu\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/inbre.hpcf.upr.edu\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/inbre.hpcf.upr.edu\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/inbre.hpcf.upr.edu\/index.php\/wp-json\/wp\/v2\/comments?post=3097"}],"version-history":[{"count":164,"href":"https:\/\/inbre.hpcf.upr.edu\/index.php\/wp-json\/wp\/v2\/pages\/3097\/revisions"}],"predecessor-version":[{"id":6373,"href":"https:\/\/inbre.hpcf.upr.edu\/index.php\/wp-json\/wp\/v2\/pages\/3097\/revisions\/6373"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/inbre.hpcf.upr.edu\/index.php\/wp-json\/wp\/v2\/media\/5203"}],"wp:attachment":[{"href":"https:\/\/inbre.hpcf.upr.edu\/index.php\/wp-json\/wp\/v2\/media?parent=3097"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}