Drug Discovery and Development Publications

2025

 Astrocytic HIV-1 Nef Expression Decreases Glutamate Transporter Expression in the Nucleus Accumbens and Increases Cocaine-Seeking Behavior in Rats

J, Pla-Tenorio; B, Velazquez-Perez; Y, Mendez-Borrero; ML, Cruz; MT, Sepulveda-Orengo; Jr., Noel RJ

Astrocytic HIV-1 Nef Expression Decreases Glutamate Transporter Expression in the Nucleus Accumbens and Increases Cocaine-Seeking Behavior in Rats

In: Pharmaceuticals (Basel), 2025.

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2024

Deferasirox's Anti-Chemoresistance and Anti-Metastatic Effect on Non-Small Cell Lung Carcinoma

Y, Delgado; A, Torres-Sanchez; D, Perez; G, Torres; S, Estrada; N, Ortiz Alvelo; J, Vega; L, Santos; A, Torres; BA, Madera; Y, Ferrer-Acosta

Deferasirox's Anti-Chemoresistance and Anti-Metastatic Effect on Non-Small Cell Lung Carcinoma

In: Biomedicines, 2024.

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Sex-specific effects of chronic stress prior to cocaine exposure on cue- vs drug-induced relapse after prolonged abstinence

RJ, Morales-Silva; Y, Perez-Perez; J, Alvarado-Torres; N, Rivera-Aviles; G, Rodriguez-Torres; U, Gelpi-Dominguez; B, Dominguez-Padovani; A, Amador-Maldonado; MT, Sepulveda-Orengo

Sex-specific effects of chronic stress prior to cocaine exposure on cue- vs drug-induced relapse after prolonged abstinence

In: Behav Brain Res, 2024.

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HL-60 cells as a valuable model to study LPS-induced neutrophil extracellular traps release

SJ, Malavez-Cajigas; FI, Marini-Martinez; M, Lacourt-Ventura; KJ, Rosario-Pacheco; NM, Ortiz-Perez; B, Velazquez-Perez; W, De Jesús-Rojas; DS, Chertow; JR, Strich; MJ, Ramos-Benítez

HL-60 cells as a valuable model to study LPS-induced neutrophil extracellular traps release

In: Heliyon, 2024.

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 Analysis of Sigma-1 Receptor Antagonist BD1047 Effect on Upregulating Proteins in HIV-1-Infected Macrophages Exposed to Cocaine Using Quantitative Proteomics

O, Vélez-López; K, Carrasquillo-Carrión; YM, Cantres-Rosario; E, Machín-Martínez; ME, Álvarez-Ríos; A, Roche-Lima; EL, Tosado-Rodríguez; LM, Meléndez

Analysis of Sigma-1 Receptor Antagonist BD1047 Effect on Upregulating Proteins in HIV-1-Infected Macrophages Exposed to Cocaine Using Quantitative Proteomics

In: Biiomedicines, 2024.

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Novel inhibition of central carbon metabolism pathways by Rac and Cdc42 inhibitor MBQ-167 and paclitaxel

AM, Cruz-Collazo; O, Katsara; N, Grafals-Ruiz; J, Colon Gonzalez; S, Dorta-Estremera; VP, Carlo; N, Chorna; RJ, Schneider; S, Dharmawardhane

Novel inhibition of central carbon metabolism pathways by Rac and Cdc42 inhibitor MBQ-167 and paclitaxel

In: Mol Cancer Ther, 2024.

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 Immune and Microbial Signatures Associated with PD-1 Blockade Sensitivity in a Preclinical Model for HPV+ Oropharyngeal Cancer

J, Díaz-Rivera; MA, Rodríguez-Rivera; NM, Meléndez-Vázquez; F, Godoy-Vitorino; SM, Dorta-Estremera

Immune and Microbial Signatures Associated with PD-1 Blockade Sensitivity in a Preclinical Model for HPV+ Oropharyngeal Cancer

In: Cancers (Basel), 2024.

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Development of a Neuropeptide Y-Sensitive Implantable Microelectrode for Continuous Measurements

L, Fernández-Vega; Meléndez-Rodríguez D and, Ospina-Alejandro M; K, Casanova; Y, Vázquez; L, Cunci

Development of a Neuropeptide Y-Sensitive Implantable Microelectrode for Continuous Measurements

In: ACS Sens., 2024.

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 Extracts Induce INFγ-Independent Activation of CIITA, MHCII, and Increases Inflammation in Human Bronchial Epithelium

H, Jirau-Colón; BD, Jiménez-Vélez

Extracts Induce INFγ-Independent Activation of CIITA, MHCII, and Increases Inflammation in Human Bronchial Epithelium

In: Toxics, 2024.

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New Regulatory roles for Human Serum Amyloid A

CG, García-Cortés; E, Parés-Matos

New Regulatory roles for Human Serum Amyloid A

In: 2024.

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Measurement of neuropeptide Y with molecularly imprinted polypyrrole on carbon fiber microelectrodes

L, López; K, Lozano; J, Cruz; K, Flores; L, Fernández-Vega; L, Cunci

Measurement of neuropeptide Y with molecularly imprinted polypyrrole on carbon fiber microelectrodes

In: Neuropeptides, 2024.

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2023

Prioritizing cardiovascular disease-associated variants altering NKX2-5 and TBX5 binding through an integrative computational approach

EG, Peña-Martínez; DA, Pomales-Matos; A, Rivera-Madera; JL, Messon-Bird; JG, Medina-Feliciano; L, Sanabria-Alberto; AC, Barreiro-Rosario; J, Rivera-Del Valle; JM, Rodríguez-Ríos; JA, Rodríguez-Martínez

Prioritizing cardiovascular disease-associated variants altering NKX2-5 and TBX5 binding through an integrative computational approach

In: J Biol Chem, 2023.

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Synergistic interactions of cytarabine-adavosertib in leukemic cell lines proliferation and metabolomic endpoints

GO, Rodríguez-Vázquez; AO, Diaz-Quiñones; N, Chorna; IK, Salgado-Villanueva; J, Tang; WIS, Ortiz; HM, Maldonado

Synergistic interactions of cytarabine-adavosertib in leukemic cell lines proliferation and metabolomic endpoints

In: Biomed Pharmacother, 2023.

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The Effects of Amyloid-β on Metabolomic Profiles of Cardiomyocytes and Coronary Endothelial Cells

S, Jang; N, Chorna; KM, Rodríguez-Graciani; M, Inyushin; S, Fossati; S, Javadov

The Effects of Amyloid-β on Metabolomic Profiles of Cardiomyocytes and Coronary Endothelial Cells

In: J Alzheimers Dis., 2023.

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2022

Hormetic effect of an Ethanolic Graviola Leaf Extract on HGF-1 cells survival

MA, Barreto-Diaz; RA, Velázquez-Aponte; A, Wu-Wu; C, Cassé

Hormetic effect of an Ethanolic Graviola Leaf Extract on HGF-1 cells survival

In: BAOJ Cancer Res The. 2022, 2022.

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Phytoremediation of CdS/Te quantum dots by Ocimum basilicum in the presence of EDTA

L, Alamo-Nole; B, Estrella-Martinez

Phytoremediation of CdS/Te quantum dots by Ocimum basilicum in the presence of EDTA

In: J Environ Health Sci Eng, 2022.

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Vinyl halogenated fatty acids display antibacterial activity against clinical isolates of methicillin-resistant Staphylococcus aureus

DJ, Sanabria-Rios; D, Alequin-Torres; A, De Jesus; G, Cortes; NM, Carballeira

Vinyl halogenated fatty acids display antibacterial activity against clinical isolates of methicillin-resistant Staphylococcus aureus

In: Med Res Arch, 2022.

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