The ChEMTox Biotesting Facility at Universidad Metropolitana (UMET) affiliated to the School of Environmental Affairs provides services for the toxicity testing of novel and natural substances on human or animal cell cultures. It supports scientist in drug development interested in characterizing the mechanism of action of natural products, novel materials or environmental contaminants.
The laboratory is also a CORE facility for researchers from the PR-INBRE program (UPR-NIH funded). Local scientists as well as scientists from the National Cancer Institute in the US have used our in-vitro testing services.
Toxicological assays for novel drugs/materials, natural products or environmental substances include:
- Determination of 50% Inhibition concentration (IC50)
- Apoptosis Annexin V assay-
- Mitochondrial Permeability JC1 • Caspase 7, 3, 8 and 9
- Cell Cycle arrest
- DNA Fragmentation
- Autophagy cell death
- Bacterial growth inhibition
- Fluorescent microscopy
- Flow cytometry analysis
- Hypoxic markers
- Among Others
Quotes and Information:
Beatriz Zayas, PhD, MS
Universidad Metropolitana ChEMTox Lab Director
PO Box 21150, San Juan PR,00926
Phone: 787-766-1717 x6460, 6462
Click here to download ChEMTox Biotesting Facilty brochure.